I use the "autopilot" a lot, but sometimes I'm in a keyboard sort of mood, and I find it a little annoying that the only way to do this is with the mouse. :)
I agree with this as well. I also wish that there was another "enter" key closer to the WASD keys since I sometimes play during my lunch break and it would be much easier to play one-handed if the E key also functioned as the Enter key. I can press W to interact with object when only one thing is highlighted, but when multiple objects get selected I have to use Enter to pick one.
I was going to ask for this, as it's the only time that I have to repeatedly remove my hands from the keyboard. Removing them for working with the map or what have you is cool since it's not terribly common, clicking that little arrow on every single street to get where you're going feels like more of a hassle than I'd prefer.