When I was in Talish Crest today, I was visited by the Rube.
I has the map auto-path on, which takes up some of the real estate in the upper right, and the stuck spinach boost.
The Rube showed up at the right edge of the screen, and his speech bubble was BEHIND the map autopath and the high jumper bubbles.
It was hard to get out of, though I think I did it by resizing the window. And maybe in the end by saying "No thanks", though he let me talk to him again.
At some point in there, in the same location, the Rube ended up off the LEFT edge of the screen. I couldn't see HIM any longer, though his speech bubble was still on screen.