Can you set up keyboard shortcuts? In particular, I'd like to access my first slot (which is a focusing orb) without having to click... because I'm lazy. Or clever, if you're feeling charitable. Or both!
Yes there are many keyboard shortcuts :) The one you are looking for is B (as in bag) and then you can use the arrow keys and enter from there. A few others include M for map, L for quest log, and crtl + enter to change between chat and playing window.
I think the OP is after macros or assignable hotkeys. Although it's not so necessary in a game like this, it would make certain daily chores a lot more fun...
Well, first, hotkeys seem to not be behaving (Win7 Chrome13.0.782.218) as expected and for once, I can't blame my own weird key mapping (idea request in 3... 2...). I will investigate more later.
I wouldn't mind assignable hotkeys (macros seem to shift near bot behavior, depending on what someone means by macro)... if that's what it takes to get my goal achieved and not create issues of their own.